ジャーナル論文 / Journal
  1. Mochizuki, A., Shiraishi, K., Honda, T., Higashiyama, R. I., Sunami, K., Matsuda, M., Shimada, Y., Miyazaki, Y., Yoshida, Y., Watanabe, S., Yatabe, Y., Hamamoto, R., and Kohno, T., "Passive smoking-induced mutagenesis as a promoter of lung carcinogenesis", Journal of Thoracic Oncology, (2024).
  2. Kobayashi, K., Gu, L., Hataya, R., Mizuno, T., Miyake, M., Watanabe, H., Takahashi, M., Takamizawa, Y., Yoshida, Y., Nakamura, S., Kouno, N., Bolatkan, A., Kurose, Y., Harada, T., and Hamamoto, R., "Sketch-based semantic retrieval of medical images", Med. Image Anal. 92, 103060, (2024).
  3. Kato, M. K., Fujii, E., Asami, Y., Momozawa, Y., Hiranuma, K., Komatsu, M., Hamamoto, R., Ebata, T., Matsumoto, K., Ishikawa, M., Kohno, T., Kato, T., Yoshida, H., and Shiraishi, K., "Clinical features and impact of p53 status on sporadic mismatch repair deficiency and Lynch syndrome in uterine cancer", Cancer Sci., (2024).
  4. Shirasawa, M., Yoshida, T., Shiraishi, K., Takigami, A., Takayanagi, D., Imabayashi, T., Matsumoto, Y., Masuda, K., Shinno, Y., Okuma, Y., Goto, Y., Horinouchi, H., Yotsukura, M., Yoshida, Y., Nakagawa, K., Tsuchida, T., Hamamoto, R., Yamamoto, N., Motoi, N., Kohno, T., Watanabe, S., and Ohe, Y., "Identification of inflamed-phenotype of small cell lung cancer leading to the efficacy of anti-PD-L1 antibody and chemotherapy", Lung Cancer 179, 107183, (2023).
  5. Shirasawa, M., Yoshida, T., Shiraishi, K., Goto, N., Yagishita, S., Imabayashi, T., Matsumoto, Y., Masuda, K., Shinno, Y., Okuma, Y., Goto, Y., Horinouchi, H., Yotsukura, M., Yoshida, Y., Nakagawa, K., Naoki, K., Tsuchida, T., Hamamoto, R., Yamamoto, N., Motoi, N., Kohno, T., Watanabe, S., and Ohe, Y., "Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer", Br. J. Cancer 129(12), 2003–2013, (2023).
  6. Ohata, H., Shiokawa, D., Sakai, H., Kanda, Y., Okimoto, Y., Kaneko, S., Hamamoto, R., Nakagama, H., and Okamoto, K., "PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway", Cell Rep. 42(6), 112519, (2023).
  7. Machino, H., Dozen, A., Konaka, M., Komatsu, M., Nakamura, K., Ikawa, N., Shozu, K., Asada, K., Kaneko, S., Yoshida, H., Kato, T., Nakayama, K., Saloura, V., Kyo, S., and Hamamoto, R., "Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas", Exp. Mol. Med. 55(10), 2205–2219, (2023).
  8. Kim, K., Ryu, T. Y., Jung, E., Han, T., Lee, J., Kim, S., Roh, Y. N., Lee, M., Jung, C., Lim, J. H., Hamamoto, R., Lee, H. W., Hur, K., Son, M., Kim, D., and Cho, H., "Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis", Exp. Mol. Med. 55(5), 952–964, (2023).
  9. Kato, H., Hayami, S., Ueno, M., Suzaki, N., Nakamura, M., Yoshimura, T., Miyamoto, A., Shigekawa, Y., Okada, K., Miyazawa, M., Kitahata, Y., Ehata, S., Hamamoto, R., Yamaue, H., and Kawai, M., "Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma", Cancer Sci. 115(2), 385–400, (2023).
  10. Ito, T., Takayanagi, D., Sekine, S., Hashimoto, T., Shimada, Y., Matsuda, M., Yamada, M., Hamamoto, R., Kato, T., Shida, D., Kanemitsu, Y., Boku, N., Kohno, T., Takashima, A., and Shiraishi, K., "Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts", Sci. Rep. 13(1), 3587, (2023).
  11. Igarashi, T., Mazevet, M., Yasuhara, T., Yano, K., Mochizuki, A., Nishino, M., Yoshida, T., Yoshida, Y., Takamatsu, N., Yoshimi, A., Shiraishi, K., Horinouchi, H., Kohno, T., Hamamoto, R., Adachi, J., Zou, L., and Shiotani, B., "An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress", Nat. Commun. 14(1), 4991, (2023).
  12. Hiranuma, K., Asami, Y., Kato, M. K., Murakami, N., Shimada, Y., Matsuda, M., Yazaki, S., Fujii, E., Sudo, K., Kuno, I., Komatsu, M., Hamamoto, R., Makinoshima, H., Matsumoto, K., Ishikawa, M., Kohno, T., Terao, Y., Itakura, A., Yoshida, H., Shiraishi, K., and Kato, T., "Rare FGFR fusion genes in cervical cancer and transcriptome‐based subgrouping of patients with a poor prognosis", Cancer Medicine 12(17), 17835–17848, (2023).
  13. Hashimoto, T., Takayanagi, D., Yonemaru, J., Naka, T., Nagashima, K., Machida, E., Kohno, T., Yatabe, Y., Kanemitsu, Y., Hamamoto, R., Takashima, A., Shiraishi, K., and Sekine, S., "A comprehensive appraisal of HER2 heterogeneity in HER2-amplified and HER2-low colorectal cancer", Br. J. Cancer 129(7), 1176–1183, (2023).
  14. Hamamoto, R., Takasawa, K., Shinkai, N., Machino, H., Kouno, N., Asada, K., Komatsu, M., and Kaneko, S., "Analysis of super-enhancer using machine learning and its application to medical biology", Brief. Bioinform. bbad107, (2023).
  15. Asami, Y., Kobayashi Kato, M., Hiranuma, K., Matsuda, M., Shimada, Y., Ishikawa, M., Koyama, T., Komatsu, M., Hamamoto, R., Nagashima, M., Terao, Y., Itakura, A., Kohno, T., Sekizawa, A., Matsumoto, K., Kato, T., Shiraishi, K., and Yoshida, H., "Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer", Br. J. Cancer 128(8), 1582–1591, (2023).
  16. Tanosaki, T., Mikami, Y., Shindou, H., Suzuki, T., Hashidate-Yoshida, T., Hosoki, K., Kagawa, S., Miyata, J., Kabata, H., Masaki, K., Hamamoto, R., Kage, H., Miyashita, N., Makita, K., Matsuzaki, H., Suzuki, Y., Mitani, A., Nagase, T., Shimizu, T., and Fukunaga, K., "Lysophosphatidylcholine Acyltransferase 1 Deficiency Promotes Pulmonary Emphysema via Apoptosis of Alveolar Epithelial Cells", Inflammation, (2022).
  17. Shozu, K., Kaneko, S., Shinkai, N., Dozen, A., Kosuge, H., Nakakido, M., Machino, H., Takasawa, K., Asada, K., Komatsu, M., Tsumoto, K., Ohnuma, S., and Hamamoto, R., "Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer", Clinical Epigenetics 14(1), (2022).
  18. Sakai, A., Komatsu, M., Komatsu, R., Matsuoka, R., Yasutomi, S., Dozen, A., Shozu, K., Arakaki, T., Machino, H., Asada, K., Kaneko, S., Sekizawa, A., and Hamamoto, R., "Medical Professional Enhancement Using Explainable Artificial Intelligence in Fetal Cardiac Ultrasound Screening", Biomedicines 10(3), (2022).
  19. Ryu, T. Y., Kim , K., Han , T., Lee , M., Lee , J., Choi , J., Jung, K. B., Jeong, E., An , . ., Jung, C., Oh, S. J., Hur, K., Hamamoto, R., Park, D., Kim , D., Son, M., and Cho, H., "Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer", The ISME Journal 16, 1205–1221 , (2022).
  20. Ono , S., Komatsu, M., Sakai, A., Arima, H., Ochida, M., Aoyama, R., Yasutomi, S., Asada, K., Kaneko, S., Sasano, T., and Hamamoto, R., "Automated Endocardial Border Detection and Left Ventricular Functional Assessment in Echocardiography Using Deep Learning", Biomedicines 10(5), (2022).
  21. Machino, H., Kaneko, S., Komatsu, M., Ikawa, N., Asada, K., Nakato, R., Shozu, K., Dozen, A., Sone, K., Yoshida, H., Kato, T., Oda, K., Osuga, Y., Fujii, T., von Keudell, G., Saloura, V., and Hamamoto, R., "The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma", Commun. Biol. 5(1), (2022).
  22. Kukita, A., Sone, K., Kaneko, S., Kawakami, E., Oki, S., Kojima, M., Wada, M., Toyohara, Y., Takahashi, Y., Inoue, F., Tanimoto, S., Taguchi, A., Fukuda, T., Miyamoto, Y., Tanikawa, M., Mori-Uchino, M., Tsuruga, T., Iriyama, T., Matsumoto, Y., Nagasaka, K., Wada-Hiraike, O., Oda, K., Hamamoto, R., and Osuga, Y., "The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells", Cancers 14(21), 5367, (2022).
  23. Kato, M. K., Asami, Y., Takayanagi, D., Matsuda, M., Shimada, Y., Hiranuma, K., Kuno, I., Komatsu, M., Hamamoto, R., Matsumoto, K., Ishikawa, M., Kohno, T., Kato, T., Shiraishi, K., and Yoshida, H., "Clinical impact of genetic alterations of CTNNB1 in patients with grade 3 endometrial endometrioid carcinoma", Cancer Sci., (2022).
  24. Hossain, E., Abdelrahim, M., Tanasescu, A., Yamada, M., Kondo, H., Yamada, S., Hamamoto, R., Marugame, A., Saito, Y., and Bhandari, P., "Performance of a novel computer‐aided diagnosis system in the characterization of colorectal polyps, and its role in meeting Preservation and Incorporation of Valuable Endoscopic Innovations standards set by the American Society of Gastrointestinal Endoscopy", DEN Open 3(1), e178, (2022).
  25. Hopkins, J., Asada, K., Leung, A., Papadaki, V., Davaapil, H., Morrison, M., Orita, T., Sekido, R., Kosuge, H., Reddy, M. A., Kimura, K., Mitani, A., Tsumoto, K., Hamamoto, R., Sagoo, M. S., and Ohnuma, S., "PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression", Cancers 14(19), 4926, (2022).
  26. Hashimoto, T., Takayanagi, D., Yonemaru, J., Naka, T., Nagashima, K., Yatabe, Y., Shida, D., Hamamoto, R., Kleeman, S. O., Leedham, S. J., Maughan, T., Takashima, A., Shiraishi, K., and Sekine, S., "Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer", Br. J. Cancer 127(6), 1043–1050, (2022).
  27. Hamamoto, R., Takasawa, K., Machino, H., Kobayashi, K., Takahashi, S., Bolatkan, A., Shinkai, N., Sakai, A., Aoyama, R., Yamada, M., Asada, K., Komatsu, M., Okamoto, K., Kameoka, H., and Kaneko, S., "Application of non-negative matrix factorization in oncology: one approach for establishing precision medicine.", Brief. Bioinform., (2022).
  28. Hamamoto, R., Koyama, T., Kouno, N., Yasuda, T., Yui, S., Sudo, K., Hirata, M., Sunami, K., Kubo, T., Takasawa, K., Takahashi, S., Machino, H., Kobayashi, K., Asada, K., Komatsu, M., Kaneko, S., Yatabe, Y., and Yamamoto, N., "Introducing AI to the molecular tumor board: one direction toward the establishment of precision medicine using large-scale cancer clinical and biological information.", Experimental hematology & oncology 11(1), 82, (2022).
  29. Dozen, A., Shozu, K., Shinkai, N., Ikawa, N., Aoyama, R., Machino, H., Asada, K., Yoshida, H., Kato, T., Hamamoto, R., Kaneko, S., and Komatsu, M., "Tumor Suppressive Role of the PRELP Gene in Ovarian Clear Cell Carcinoma", Journal of Personalized Medicine 12(12), 1999, (2022).
  30. Lee, J., Kim, K., Ryu, T. Y., Jung, C., Lee, M., Lim, J. H., Park, K., Kim, D., Son, M., Hamamoto, R., and Cho, H., "EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression", Molecular Oncology 15(11), 2989–3002, (2021).
  31. Kuno, I., Takayanagi, D., Asami, Y., Murakami, N., Matsuda, M., Shimada, Y., Hirose, S., Kato, M. K., Komatsu, M., Hamamoto, R., Okuma, K., Kohno, T., Itami, J., Yoshida, H., Shiraishi, K., and Kato, T., "TP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer", Sci. Rep. 11(1(19261)), (2021).
  32. Kobayashi, K., Miyake, M., Takahashi, M., and Hamamoto, R., "Observing Deep Radiomics for the Classification of Glioma Grades", Scientifc Reports 11(1), (2021).
  33. Kobayashi, K., Hataya, R., Kurose, Y., Miyake, M., Takahashi, M., Nakagawa, A., Harada, T., and Hamamoto, R., "Decomposing normal and abnormal features of medical images for content-based image retrieval of glioma imaging", Med. Image Anal. 74, (2021).
  34. Kawaguchi, R. K., Takahashi, M., Miyake, M., Kinoshita, M., Takahashi, S., Ichimura, K., Hamamoto, R., Narita, Y., and Sese, J., "Assessing Versatile Machine Learning Models for Glioma Radiogenomic Studies across Hospitals", Cancers (Basel) 13(14), (2021).
  35. Kaneko, S., Mitsuyama, T., Shiraishi, K., Ikawa, N., Shozu, K., Dozen, A., Machino, H., Asada, K., Komatsu, M., Kukita, A., Sone, K., Yoshida, H., Motoi, N., Hayami, S., Yoneoka, Y., Kato, T., Kohno, T., Natsume, T., Keudell, G. v., Saloura, V., Yamaue, H., and Hamamoto, R., "Genome-Wide Chromatin Analysis of FFPE Tissues Using a Dual-Arm Robot with Clinical Potential", Cancers (Basel) 13(9), (2021).
  36. Bolatkan, A., Asada, K., Kaneko, S., Suvarna, K., Ikawa, N., Machino, H., Komatsu, M., Shiina, S., and Hamamoto, R., "Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules", Int. J. Oncol. 60(1(4)), (2021).
国際会議 / Proceedings
  1. Kobayashi, K., Gu, L., Hataya, R., Miyake, M., Takamizawa, Y., Ito, S., Watanabe, H., Yoshida, Y., Yoshimura, H., Harada, T., and Hamamoto, R., "Towards AI-Driven Radiology Education: A Self-supervised Segmentation-Based Framework for High-Precision Medical Image Editing", Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 , (2023).
レビュー / Review
  1. Yamada, M., Saito, Y., Yamada, S., Kondo, H., and Hamamoto, R., "Detection of flat colorectal neoplasia by artificial intelligence: A systematic review", Best Practice & Research Clinical Gastroenterology 52-53, (2021).
  2. Takahashi, S., Takahashi, M., Tanaka, S., Takayanagi, S., Takami, H., Yamazawa, E., Nambu, S., Miyake, M., Satomi, K., Ichimura, K., Narita, Y., and Hamamoto, R., "A New Era of Neuro-Oncology Research Pioneered by Multi-Omics Analysis and Machine Learning", Biomolecules 11(4), (2021).
  3. Komatsu, M., Sakai, A., Dozen, A., Shozu, K., Yasutomi, S., Machino, H., Asada, K., Kaneko, S., and Hamamoto, R., "Towards Clinical Application of Artificial Intelligence in Ultrasound Imaging", Biomedicines 9(7), (2021).
  4. Kaneko, S., Takasawa, K., Asada, K., Shinkai, N., Bolatkan, A., Yamada, M., Takahashi, S., Machino, H., Kobayashi, K., Komatsu, M., and Hamamoto, R., "Epigenetic Mechanisms Underlying COVID-19 Pathogenesis", Biomedicines 9(9), (2021).
  5. Asada, K., Takasawa, K., Machino, H., Takahashi, S., Shinkai, N., Bolatkan, A., Kobayashi, K., Komatsu, M., Kaneko, S., Okamoto, K., and Hamamoto, R., "Single-Cell Analysis Using Machine Learning Techniques and Its Application to Medical Research", Biomedicines 9(11), 1513, (2021).
  6. Asada, K., Komatsu, M., Shimoyama, R., Takasawa, K., Shinkai, N., Sakai, A., Bolatkan, A., Yamada, M., Takahashi, S., Machino, H., Kobayashi, K., Kaneko, S., and Hamamoto, R., "Application of Artificial Intelligence in COVID-19 Diagnosis and Therapeutics", Journal of Personalized Medicine 11(9), (2021).
  7. Asada, K., Kaneko, S., Takasawa, K., Machino, H., Takahashi, S., Shinkai, N., Shimoyama, R., Komatsu, M., and Hamamoto, R., "Integrated Analysis of Whole Genome and Epigenome Data Using Machine Learning Technology: Toward the Establishment of Precision Oncology", Front. Oncol. 11, (2021).